Endocrine Abstracts

Drug-induced Hyperprolactinaemia is commonly observed and frequently poses diagnostic and managerial difficulties. Clearly, it is important to ensure that there is no underlying pathological cause, such as a hypothalamic or pituitary tumour, which would need addressing separately. Anti-psychotic medications are a common cause of this condition, although this is not observed in some newer atypical antipsychotics. Other common causes include anti-depressants, anti-hypertensives,...

Introduction: We describe a case of young girl, who initially presented with androgen producing adrenal adenoma, and post-operatively, the other adrenal gland profoundly cortisol suppressed, raising suspicion, if it was originally co-producing both androgen and cortisol.Case report: A 29-year-old girl initially presented, with 8 months history of hirsutism and cranial hair loss.She had a normal menarche and menstrual cycles and con...

Introduction: We describe a case of young girl, who initially presented with androgen producing adrenal adenoma, and post-operatively, the other adrenal gland profoundly cortisol suppressed, raising suspicion, if it was originally co-producing both androgen and cortisol.Case report: A 29-year-old girl initially presented, with 8 months history of hirsutism and cranial hair loss.She had a normal menarche and menstrual cycles and con...

68 Y M Has Background of Hypertension and Asthma. Presented with progressive visual deterioration for 12 months in 2012. VF testing confirmed Bitemporal Hemianopia. He has symptoms suggestive of cortisol excess. Therefore, MRI pituitary and pituitary hormone profile was done. MRI showed pituitary macroadenoma A Pituitary Hormone profile in 2012 showed cortisol excess at value of 755 nmol/l and ACTH 156 ng/l(0–46). IGF-1 17.2 nmol/l which is normal. LDDST was done and cortisol ...

Background: The plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenoma. Mixed Growth hormone and prolactin secreting adenomas are the commonest one, approximately 5% of surgically removed adenoma. Other hormonal mixture of adenoma may occur, but very rare. We present a rare case of co-secreting TSH and GH adenoma. Clinical Case: A 45 year old gentleman, generally fit and well, presented with 3 years history of blurred visi...

Section 1: Case History: A 45-year-old gentleman attended the emergency department in December 2016 with an episode of stupor, confusion and lethargy with blood glucose of 1.8 mmol/l. He recovered after administration of IV glucose. He had ’funny spells’ for a year prior to the event. He had a history of childhood asthma and was not on any regular medications. There were no significant findings in the clinical examination and no relevant family history. <p class=...

Case history: We present a rare case of Langerhans cell histiocytosis (LCH) of pituitary stalk and hypothalamus in a 40 year old lady. She presented with 9 weeks history of a sudden onset of polyuria and polydipsia. She had extreme thirst even during night which led to significant nocturia and tiredness. She denied headache, blurring of vision, galactorrhoea or menstrual irregularity. She had no significant past medical history and was not on any medications. Physical examinat...

Case history: A 42-year-old lady was referred from neurology clinic after being assessed for symptoms of headaches, dizziness, transient visual problems and paraesthesia over her limbs for 2 months. On review, she complained of amenorrhoea and was noted to be pale, however, her neurological examination including visual fields to confrontation and ocular movements were normal. Subsequent investigations were consistent with pan-hypopituitarism and she was promptly commenced on h...

Case notes of 150 consecutive patients (58% male) who underwent pituitary surgery by a single surgeon for non-functioning pituitary adenoma and endocrine follow up at our centre between July 2005 and February 2015 were reviewed. All patients underwent endoscopic transsphenoidal surgery as the first approach. Post-operative pituitary function was assessed by measurement of baseline pituitary hormonal profile and a glucagon stimulation test to assess ACTH and GH axis. Mean age a...

Introduction: Current literature suggests that the incidence of GH deficiency (GHD) post subarachnoid haemorrhage (SAH) ranges from 0 to 37%. We present the results from a large single centre study and discuss factors that should be considered when testing for GHD in this population.Method: One hundred survivors of SAH were screened with a glucagon stimulation test (GST) for pituitary hormone deficiency. Participants with isolated GHD were required to un...